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Kratom Potentiators: How to Use Them Safely, Options & More

February 7, 2023MixingNo Comments »

Kratom is an herbal supplement that can have different effects on the body. While it is generally considered safe when taken in moderation, some users may need to take more than the recommended dosage to achieve the desired kratom effects. In cases of increased kratom tolerance, adding a potentiator can be beneficial as it can help enhance the effects of kratom without increasing the amount you need to take.

Still, it is crucial to understand how to potentiate kratom safely and which options are available to ensure your safety and maximize the potential benefits. In this article, we will discuss what kratom potentiators are and how they work, as well as provide some tips for potentiating kratom effectively and reducing health risks.

What Are Kratom Potentiators and Why Are They Used? 

Kratom potentiators are substances that can be used to enhance the effects of kratom. Kratom is a natural plant-based supplement used for centuries in Southeast Asia for its medicinal properties. It is known to have numerous effects, such as relaxation and improved energy and focus. By using kratom potentiators, users can increase the potency of their kratom and experience more pronounced results.

Types of Kratom Potentiators

If you want to enhance your kratom’s effects, potentiators are the way to go. Kratom potentiators come in many forms, from grapefruit juice to cayenne pepper, turmeric, and more. These offer properties that can help to boost the power of your kratom dose.

Natural Potentiators

Here is a list of natural potentiators that you can try with your usual kratom dose: 

image of turmeric kratom natural potentiators


Turmeric is a powerful natural potentiator that can be used to amplify the effects of kratom. Turmeric contains curcumin, which can help boost the body’s natural ability to absorb kratom, allowing more of its active alkaloids to be absorbed into the bloodstream. This increases the cogency of kratom’s effects, making them more powerful and longer-lasting. They may also work together to provide a calming yet energizing effect.


Magnesium is a mineral found in many foods and supplements and has been known as an excellent potentiator for centuries. Magnesium increases the bioavailability of kratom alkaloids, allowing them to be absorbed more quickly and efficiently into the body. This means that users can experience more substantial effects from smaller doses of kratom strains. Magnesium also helps reduce kratom tolerance levels, so users don’t need to increase their dose over time to achieve the same effects.

image of ginger kratom natural potentiators


Ginger is also known for its calming and soothing effects, which can help improve digestion and reduce nausea, making it easier for your body to absorb the active ingredients in kratom. Combining ginger with kratom gives you an even better experience that can help you achieve greater relaxation and pain relief.

Grapefruit Juice

Grapefruit juice is one of the most popular and effective kratom potentiators. The active compounds in grapefruit juice interact with the alkaloids in kratom, resulting in increased absorption and enhanced effects. With grapefruit juice, users can get more out of their kratom dose while also experiencing a longer-lasting impact.

image of black pepper kratom natural potentiators

Black Pepper

The active ingredient in black pepper, piperine, works by inhibiting certain enzymes in the body that break down and metabolize compounds like those found in kratom. By blocking these enzymes, piperine allows more of the compounds found in kratom to remain intact and be absorbed into the body.


When taken together, caffeine enhances the effects of kratom by increasing its strength and duration. Caffeine increases the absorption rate of alkaloids in kratom, allowing them to enter the bloodstream faster and remain in the body longer. Additionally, caffeine helps to reduce fatigue and improve mental clarity when taken with kratom.

image of valerian root kratom natural potentiators

Valerian Root

Valerian root is a popular herbal supplement used to promote relaxation. When combined with kratom, valerian root can act as a potentiator, enhancing the effects of kratom while also providing calming benefits. By combining these two powerful herbs, users can experience improved well-being and relaxation without having to take higher doses of either.

Cat’s Claw

Cat’s Claw is a medicinal herb native to the Amazon rainforest that has been used for centuries by indigenous tribes for its strong health properties. It is known as a potentiator, enhancing the effects of other substances, such as kratom. Cat’s Claw works by elevating the absorption rate of kratom’s alkaloids in the body, allowing them to be more available and providing a more robust effect than when taken by itself.

image of kava kratom natural potentiators


Kava is made from the root of the Piper methysticum plant and is known for its calming and relaxing effects. Kava works by increasing serotonin levels in the brain, which helps provide an uplifting feeling. Additionally, it increases dopamine levels, which can help improve focus and concentration. When taken alongside kratom, users experience greater relaxation and improved moods without adverse side effects.

Synthetic Potentiators

Warning: Please bear in mind that some/most of these synthetic potentiators are not FDA-approved and may be illegal or controlled substances in certain countries.


DXM taken with kratom can increase the intensity of the effects of kratom. DXM works by blocking serotonin reuptake transporters in the brain, which increases serotonin levels and amplifies the effects of other substances like kratom. Additionally, DXM can increase dopamine levels in the brain, further enhancing kratom’s effects.

image of phenibut synthetic potentiators


Phenibut is a psychoactive drug used as a nootropic and anxiolytic for decades. It is a derivative of the neurotransmitter GABA and works by binding to GABA receptors in the brain, leading to enhanced mood, improved cognition, and relaxation. The combination of phenibut and kratom can result in increased energy, improved focus, and improved sleep quality.


 Chlorpheniramine is an antihistamine commonly used to treat symptoms of allergies, hay fever, and the common cold. When taken with kratom, chlorpheniramine can increase the effects of kratom by blocking specific brain receptors responsible for breaking down kratom’s active alkaloids. This combination usually increases sedation.


Cimetidine, also known by its brand name Tagamet, is an over-the-counter medication used to treat heartburn and other gastrointestinal issues. Cimetidine works by inhibiting the enzymes responsible for breaking down kratom alkaloids in the body, allowing them to remain active for extended periods and providing a more intense experience.

image of is it safe to potentiate kratom

Is It Safe to Potentiate Kratom?

Potentiating your kratom can get you the effects you’re looking for, but it’s important to remember that there is a potential for enhanced effects or adverse reactions. Therefore, whether you’re an experienced user or just starting, it’s essential to use potentiators in an informed, cautious fashion.

 Knowing how different supplements interact with kratom and how those interactions may affect desired outcomes and risks will help you make good choices and enjoy your experiences without exposing yourself to undue risk. When done responsibly, potentiating is an excellent way to maximize your kratom experiences.


 Kratom potentiators are powerful substances that affect the body’s metabolism and increase the strength of kratom when taken in combination. However, if used carelessly or without due diligence, their use can cause several serious and potentially dangerous health problems. Known issues include palpitations, nausea, vomiting, and an increased risk of addiction to kratom and other drugs. 

Safety Tips

Here are some safety tips when using kratom potentiators:

1. Start low and go slow.

When using kratom potentiators, starting with a low dose and gradually increasing it over time is a best practice. This will help you gauge how your body responds to the combination of substances and avoid potential adverse reactions. 

2. Monitor your reactions.

Pay close attention to how your body reacts when taking kratom potentiators, and stop using them if you experience any adverse side effects, such as nausea, dizziness, or headaches. 

3. Talk to your doctor.

If you are considering taking kratom potentiators, it’s always best to consult your doctor to ensure they won’t interact negatively with any medications you may be taking or cause any other health issues.

How to Potentiate Kratom Safely

Here are some tips and notes on how you can safely potentiate kratom: 

Grapefruit JuiceCombine your Kratom in 8 ounces of juice or utilize the popular toss-and-wash method and chase with your preferred beverage.The toss-and-wash method is easy and works quickly. Put a teaspoonful of kratom powder in your mouth and swallow with a big gulp of juice. This can be done anywhere, anytime, so it's ideal if you need a boost on the go. Alternatively, mixing the powder into 8 ounces of your favorite juice is a more sustained approach as the effects will come on slower due to digestion.
TurmericThe mix is as easy as it gets. Add one teaspoon of turmeric to your Kratom dosage, and you’re good to go.Not only does this make your daily ritual quick, but you can have your dose in the form of a hot cup of tea, a delectable milkshake, or even mixed with yummy fruit juice. An added bonus is that the combination gives you an extra nutritious boost and helps make taking your medicine more palatable.
ChamomileAll you need to do is add your desired dose of red vein Kratom to your chamomile tea, stirring until it is completely blended in.The naturally occurring compounds in chamomile tea can help alleviate stress, reduce irritability, and fight off insomnia. In addition, red vein kratom has been known to enhance physical and mental well-being, making it an ideal combination for somebody trying to relax before bed.

Stacking Potentiators

Stacking potentiators is a concept that involves combining multiple potentiators to achieve an enhanced effect. By stacking multiple potentiators, the effects of the combined substances can be amplified and produce a more powerful result.

image of potential benefits of kratom potentiators

Potential Benefits

1. Improved Mood and Concentration

One benefit of taking a kratom potentiator is improved mood and concentration. Kratom can cause some people to experience an elevated sense of well-being. Taking a kratom potentiator can help increase these effects, enhancing focus and mental clarity.

2. Enhanced Cognitive Function

Kratom potentiators can help improve cognitive function by increasing the amount of beneficial alkaloids in the kratom. This can lead to improved memory and reaction times and increased energy levels. 

3. Mood-Boosting Effects

Kratom potentiators can also help to boost mood by increasing the levels of serotonin and other neurotransmitters in the brain. This can lead to improved feelings of happiness and relaxation.

Potential Risks

1. Interactions With Other Substances

It’s important to remember that kratom potentiators can interact with other substances, such as medications or supplements. Always consult a doctor before taking any substance in combination with kratom, as some combinations can have dangerous side effects. 

2. Overdosing on Potentiators

It is possible to overdose on potentiators, so it’s vital to stick to the recommended dosage. Taking too much of a potentiator can lead to severe health issues, such as nausea, vomiting, and dizziness.

3. Mental Health Concerns

Some individuals may be more prone to experiencing strong mental effects when taking kratom with potentiators. If you have a history of mental health issues, you must speak to your doctor before taking kratom with any potentiator. 

image of tips for stacking potentiators safely

Tips for Stacking Potentiators Safely 

Here are some tips to help stack potentiators safely and avoid severe health risks.

1. Start with a low dose.

When stacking kratom with multiple potentiators, start with a lower dose than what is recommended on the package. This will help ensure you don’t experience any adverse effects from the combination.

2. Stay hydrated.

Be sure to stay hydrated when taking kratom with any potentiator. Taking enough liquids helps reduce the risk of dehydration and other potential side effects.

3. Practice due diligence.

Before you take any potentiator, please be sure to do your research and read up on potential interactions. Educating yourself can ensure that you take the right combination for your needs.


Kratom potentiators are a great way to enhance the effects of kratom, but it’s essential to be aware of possible risks. Make sure you take the necessary precautions and follow these tips for stacking potentiators safely so you experience the benefits without any negative consequences.

With proper research and by following safety guidelines, kratom potentiators can be an excellent way to maximize the potential of kratom and experience improved mental clarity and increased energy levels.

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